Drug resistance pattern of Mycobacterium leprae from mouse footpad cultivation between 1997 to 2013 in Malaysia
نویسندگان
چکیده
منابع مشابه
The mouse foot-pad technique for cultivation of Mycobacterium leprae.
Although multiplication of Mycobacterium leprae in the foot pads of immune-competent mice is limited, and no leprosy-like lesions are produced in these animals, the mouse foot-pad system represents the first truly useful and reproducible animal model of M. leprae infection. Its employment has enabled research into basic questions with respect to the microbiology of M. leprae, and the epidemiolo...
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Ultrastructural changes in cells of the mouse footpad are described which occurred during the log phase of multiplication, the plateau, and the stationary phase of growth of Mycobacterium leprae.BALB/c mice were inoculated in the right hind footpad with 5 x 10(3) organisms and sacrificed in pairs at 86 to 173 days after inoculation. Tissue samples were prepared for electron microscopy by standa...
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Drug resistance (especially multiple drug resistance) in Mycobacterium tuberculosis makes global concerns in treatment and control of tuberculosis. Rapid diagnosis of drug resistant strains of the bacteria has vital importance in the prognosis of the disease. The aim of this study was to identify the mutations responsible for drug resistance in Mycobacterium tuberculosis strains derived from pa...
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Mycobacterium leprae, despite being recognized as a human pathogen over 140 years ago, remains uncultivable in microbiological culture media or in cell culture systems. Although it is now well established that M. leprae prefers cooler temperatures, slightly acidic microaerophilic conditions, and lipids rather than sugars as an energy source, the exact parameters for a defined axenic medium that...
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Although the prevalence of leprosy has significantly decreased since the introduction of theWorld Health Organization (WHO) regimen of multidrug therapy (MDT), the incidence remains high, with a report of approximately 215 656 cases globally in 2013. Among these, 126 913 cases were reported from India alone [1]. Of a total number of 3196 relapse cases, India alone contributed 486 cases [1]. For...
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ژورنال
عنوان ژورنال: Leprosy Review
سال: 2017
ISSN: 2162-8807
DOI: 10.47276/lr.88.4.463